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Neisseria meningitidis antibiotic

Antibiotic resistance in Neisseria meningitidi

  1. Antibiotic resistance in Neisseria meningitidis Penicillin has long been recognized as the antibiotic of choice for treatment of meningococcal infections, but clinicians have recently become concerned about the susceptibility of meningococci to penicillin and other antibiotics used in the management of meningococcal disease
  2. MICROBIOLOGY Neisseria meningitidis (the meningococcus) is a fastidious Gram-negative diplococcus that colonizes and invades only man. In genetic terms, its closest relative is the gonococcus, Neisseria gonorrhoeae. The entire genetic sequences of a serogroup A and a serogroup B meningococcus have been published
  3. Meningococcal disease is a contagious bacterial disease caused by the bacteria Neisseria meningitidis (N meningitidis) with high fatality rates: up to 15% for infection of the central nervous system (meningitis) and up to 50% to 60% among patients with blood stream infection and shock; up to 15% of survivors are left with severe neurological deficits
  4. Neisseria meningitidis (Nm, the meningococcus) is a leading cause of bacterial meningitis throughout the world. Besides meningitis, meningococci can cause sepsis, pneumonia and, occasionally, focal infections such as arthritis, myocarditis, pericarditis, endophthalmitis, epiglottitis, otitis and urethritis
  5. Neisseria meningitidis(the meningococcus) causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis and/or septicemia. In this review, we describe the biology, microbiology, and epidemiology of this exclusive human pathogen

Neisseria meningitidis is a gram-negative diplococci (spheres clumped in pairs) bacteria. Meningitis and septicemia constitute the majority of cases of meningococcal disease. Other illnesses include septic arthritis, pneumonia, and rarely pericarditis. Only cases of invasive meningococcal disease (sterile site) are reportable and require a contact investigation Historically, N. meningitidis isolates in the United States have largely been susceptible to the antibiotics recommended for treatment and prophylaxis, including penicillin and ciprofloxacin. This report describes detection of penicillin-resistant and ciprofloxacin-resistant N. meningitidis serogroup Y (NmY) isolates in the United States Antibiotic-resistant Neisseria meningitidis Serogroup Y CDC recently reported multiple cases of β-lactamase-producing N. meningitidis serogroup Y in the United States, including eleven cases also resistant to ciprofloxacin Neisseria meningitidis (N. meningitidis) was first discovered in 1887 by Weichselbaum from analyzing the cerebrospinal fluid (CSF) of a patient infected with meningitis.[1] It is a human-specific bacterium that causes a multitude of illnesses, collectively termed meningococcal disease. Surprisingly, up to 10% of the general population carry the bacteria in their nose and throat without any. Shifts in the Antibiotic Susceptibility, Serogroups, and Clonal Complexes of Neisseria meningitidis in Shanghai, China: A Time Trend Analysis of the Pre-Quinolone and Quinolone Eras. PLOS Medicine, Vol. 12, Issue. 6, p. e1001838

Neisseria meningitidis is a gram-negative diplococcus that is closely related to the gonococcus. It causes a spectrum of disease, ranging from transient fever and bacteremia to menin-gitis and fulminant septicemia. For many years penicillin has been recognized as the antibiotic of choice for meningococca The most recent MMWR included a report about a novel, emerging strain of beta-lactamase-producing Neisseria meningitidis in the United States that is resistant to both penicillin and ciprofloxacin Neisseria meningitidis is a Gram-negative diplococci with 13 distinct serotypes. It inhabits the mucosal surface of nasopharynx and oropharynx [].However, about 90% of human disease are caused by serogroup A, B, C, X, Y, and W135 [].About 5-10% of healthy people carry N. meningitidis in the nasopharynx and oropharynx and during epidemics, the carrier state rises to 70-80% [] harbor strains of Neisseria meningitidis, especially during winter months. Less than 1% of persons harboring strains of Neisseria meningitidis develop invasive disease. In the absence of exposure to a person with invasive meningococcal infection, persons with pharyngeal colonization do not require antibiotic therapy

Once the organism is identified as N meningitidis, patients are typically treated with penicillin or ampicillin, antibiotics with a narrower spectrum of activity that's less likely to lead to.. Meningococcal disease is a sudden-onset, life-threatening illness caused by the bacterium Neisseria meningitidis. Prompt antibiotic treatment can reduce morbidity and mortality among patients and antibiotic prophylaxis can prevent secondary disease in close contacts (https://redbook.solutions.aap.org/chapter.aspx?sectionid=189640131&bookid=220 Neisseria meningitidis is the most common cause of bacterial meningitis in children and is a leading cause of meningitis in adults. N. meningitidis lives harmlessly in the mucous membranes of the nose and throat of 10%-20% of human beings. These symptom-free (asymptomatic) carriers are crucial to the transmission of N Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening sepsis. The bacterium is referred to as a coccus because it is round, and more specifically, a diplococcus because of its tendency to form pairs Persistence of Neisseria meningitidis in the upper respiratory tract after intravenous antibiotic therapy for systemic meningococcal disease. J Infect Dis 1985; 151:370. Artenstein MS, Lamson TH, Evans JR. Attempted prophylaxis against meningococcal infection using intramuscular penicillin

Resistance of Neisseria meningitidis raises concern because of severity of disease caused by this organism and the need for immediate treatment of infected patients. We report an imported case of meningococcal disease caused by fluoroquinolone-resistant N. meningitidis 1, meningococcemia, meningococcal infection, meningococcal meningitis. CHARACTERISTICS: Neisseria meningitidis belongs to the family Neisseriaceae 2. It is a Gram-negative, non-spore forming, non-motile, encapsulated, and non acid-fast diplococci, which appears in kidney bean shape under the microscop

Neisseria meningitidis - Infectious Disease and

N. meningitidis is spread through the exchange of respiratory and throat secretions via activities like coughing or kissing.In addition to those who are in close contact with those infected by N. meningitidis, college students living in dorms are considered at increased risk of acquiring the infection.Antibiotic prophylaxis is suggested for those who were potentially exposed to the bacterium Neonatal conjunctivitis caused by Neisseria meningitidis is a rare occurrence. Using whole-genome sequencing, we analyzed an isolate of N. meningitidis from a 3-day-old infant in New York, USA, who was given a diagnosis of unilateral conjunctivitis Pathogenic bacteria have evolved numerous mechanisms to evade the human immune system and have developed widespread resistance to traditional antibiotics. We studied the human pathogen Neisseria meningitidis and present evidence of novel mechanisms of resistance to the human antimicrobial peptide LL-37. We found that bacteria attached to host epithelial cells are resistant to 10 μM LL-37.

Neisseria gonorrhea, on the other hand, continues to develop resistance; the acquired resistance due to selective pressure generated by the use of antibiotics is considered the main element. Approximately 75 percent of cases with invasive disease have meningitis (typically causing headache, photophobia and neck stiffness). Infants present with less-specific features. Other locations of invasive disease with Neisseria meningitidis are possible though rare, such as orbital cellulitis, septic arthritis, and pericarditis

Antibiotics for preventing meningococcal infections Cochran

Meningococcal meningitis is caused by the bacteria Neisseria meningitidis (also known as meningococcus). Meningococcus is the most common cause of bacterial meningitis in children and teens. It is a leading cause of bacterial meningitis in adults. The infection occurs more often in winter or spring. It may cause local epidemics at boarding. A total of 240 samples were collected (115 from males and 125 from females). The mean age of study participants was 11.1 years. The prevalence of nasal carriage for Neisseria meningitidis was 20.4% (49/240). Carriage was significantly higher among children living under crowded conditions (OR 1.268; 95% CI: 1.186-1.355; p = 0.006) Penicillin has long been recognized as the antibiotic of choice for treatment of meningococcal infections, but clinicians have recently become concerned about the susceptibility of meningococci to penicillin and other antibiotics used in the management of meningococcal disease. Strains relatively resistant to penicillin (minimum inhibitory concentrations ranging from 0.1 mg/L to 1.28 mg/L. The Neisseria meningitidis bacterium is usually spread through close, personal or prolonged contact with respiratory or oral secretions. Unlike a cold or the flu, the bacteria that cause meningitis cannot be spread by casual contact or by breathing the air where an infected person has been Keywords: Carriage, N. meningitidis, School children, Antimicrobial susceptibility Background Neisseria meningitidis is a Gram-negative diplococci with 13 distinct serotypes. It inhabits the mucosal surface of nasopharynx and oropharynx [1]. However, about 90% of human disease are caused by serogroup A, B, C, X, Y, and W135 [2]

Neisseria meningitidis can cause life-threatening bacterial meningitis primarily in children and young adults. Although two highly effective vaccines are available to prevent disease — one polyvalent against serogroups A, C, W, and Y, the other monovalent against serogroup B — the incidence of disease remains at about 400 cases per year in the U.S., with a mortality of 10% to 15% Background Neisseria meningitidis is nearly always susceptible to the penicillins, the cephalosporins, and chloramphenicol. Between 1987 and 1996, however, chloramphenicol-resistant strains were is..

Neisseria meningitidis. SYNONYM OR CROSS REFERENCE: Meningococcal meningitis, Meningococcal infection, cerebrospinal fever, meningococcemia. CHARACTERISTICS: Gram negative diplococci, intra or extra-cellular; multiple serogroups - 13 recognized groups (Groups A, B, C, X, Y, Z and W135 are frequently occurring); infection of the CSF Invasive Neisseria meningitidis (N. meningitidis) infection (meningitis, meningococcemia) is associated with high mortality and morbidity worldwide despite the use of proper antibiotics.Fever. Result. A total of 240 samples were collected (115 from males and 125 from females). The mean age of study participants was 11.1 years. The prevalence of nasal carriage for Neisseria meningitidis was 20.4% (49/240). Carriage was significantly higher among children living under crowded conditions (OR 1.268; 95% CI: 1.186-1.355; p = 0.006) Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast with the trend of increasing resistance, clinical isolates that. Greece, the antibiotic sensitivities of these bacteria to some common antibiotics were determined. There are reports of Neisseria meningitidis with reduced sensitivity to penicillin isolated from patients in Spain [1, 2], South Africa [3], and the United Kingdom [4, 5]. A small proportion of these penicillin-insensitiv

Meningococcal meningitis - WH

Neisseria meningitidis is a Gram-negative, non-spore forming, non-motile, encapsulated, and non-acid-fast diplococci, which appears in kidney bean shape under the microscope. There are thirteen types (serogroups) of Neisseria meningitidis, nine of which cause invasive diseas Neisseria meningitidis is a gram negative diplococcal bacterium, with the adjacent sides flattened against each other.N. meningitidis is aerobic, susceptible to drying out and growth is inhibited by free fatty acids (1). Its natural habitat is in the nasopharyngeal tract in humans. The cell wall had lipopolysaccharides, which acts as an endotoxin Neisseria meningitidis is an obligate human commensal bacterium that frequently colonises the upper respiratory tract. Person-to-person transmission occurs via direct contact or through dispersion of respiratory droplets from a carrier of the bacteria, and can lead to invasive meningococcal disease. Rare sporadic cases of meningococcal urogenital and anorectal infections, including urethritis. Although antimicrobial resistance has been uncommon among Neisseria meningitidis isolates, novel strains resistant to ciprofloxacin and penicillin have recently been identified (NEJM JW Infect Dis Sep 2020 and MMWR Recomm Rep 2020 Jun 19). In N. meningitidis, penicillin resistance is associated with the β-lactamase gene bla ROB-1 whereas ciprofloxacin resistance is associated with a mutation. Neisseria meningitidis is immediately reportable on first knowledge or suspicion of the diagnosis due to Attachment 2 also contains the recommended antibiotics and dosing for chemoprophylaxis. If possible, the investigator should obtain information on close contacts from the case. If th

Neisseria meningitidis: Biology, Microbiology, and

Neisseria meningitidis is a Gram-negative diplococcus, typically flattened where the cocci meet. Aerobic (def). There are 13 serogroups of meningococci. Serogroups B and C commonly cause meningitis (def) and meningococcemia (def) in developed countries; serogroups Y and W135 typically cause pneumonia Up-to-date information regarding the antibiotic susceptibility of Neisseria meningitidis strains from African countries is highly limited. Our aim was to comprehensively describe the antibiotic susceptibilities of a selection of N. meningitidis isolates recovered between 2000 and 2006 from 18 African countries, mainly those within the meningitis belt In all likelihood, horizontal gene transfers from other neisseria species introduced sulfonamide and β-lactam antibiotic resistance into some N. meningitidis strains. 26 N. lactamica with. Neisseria meningitidis was prefixed in 2.5% Glutaraldehyde diluted in PHEM (Pipes, Hepes, EGTA and MgSO 4) buffer at pH 7. The cells were prefixed for 1 hr at room temperature, followed by two washes in PHEM buffer. The samples were applied onto the cover glass (1.5 mm) pre-coated with poly-L-Lysine (Neisseria meningitidis) What is meningococcal meningitis? Meningitis is a severe infection of the bloodstream and meninges (a thin lining covering the brain and spinal cord) caused by a bacteria or virus. Bacterial meningitis is usually more severe than viral meningitis but is less common

  1. Eukaryotic peptidyl-prolyl cis-trans isomerases (rotamases) fall into two classes, the cyclophilins inhibited by cyclosporin A and the FK506-binding proteins inhibited by the macrolide antibiotic FK506. In prokaryotes homologs of cyclophilins have been identified and found to have rotamase activity. Sequence similarities have been noted between FK506-binding proteins and gene products in a.
  2. Antibiotics are only recommended as a preventative measure for those persons exposed to a person with meningitis caused by the bacteria Neisseria meningitidis or certain forms of Haemophilus . When a single instance of Neisseria meningitidis occurs, the state and county health departments work together to insure tha
  3. ed for 43 children who had fever in the presence or absence of focal signs of infection. Bacteremia was quantitated by the previously described procedure using heparinized blood (0.2 to 1.0 mL)

Neisseria gonorrhoeae and Neisseria meningitidis are Gram-negative diplococci.N. gonorrhoeae is the causative agent of gonorrhoea and is transmitted via sexual contact.N. meningitidis is transmitted via respiratory droplets leading to colonization of the nasopharynx and can cause meningitis and septicemia.. This important reference volume provides research scientists, advanced students. Neisseria meningitidis. N.meningitidis is a Gram-negative coccus (round shape) that is the major cause of bacterial meningitis worldwide.N.meningitidis is divided into 'serogroups' based on the differences in their surface molecules and how the immune system responds to this. Serogrouping of N. meningitidis is done by looking at the similarity of their capsule (a sugary layer around the cell) Neisseria meningitidis, a bacterium usually associated with meningitis and sepsis, is the cause of a recent cluster of sexually transmitted infections in Columbus, Ohio and in other US cities. The. Neisseria meningitidis (meningococcus). This bacterium is another leading cause of bacterial meningitis. These bacteria commonly cause an upper respiratory infection but can cause meningococcal meningitis when they enter the bloodstream. This is a highly contagious infection that affects mainly teenagers and young adults

Detection of Ciprofloxacin-Resistant, β-Lactamase

illness requiring prompt antibiotic treatment for patients and antibiotic prophylaxis for their close contacts. Neisseria meningitidis isolates in the United States have been largely susceptible to the antibiotics recommended for treatment and prophylaxis. However, 11 meningococcal disease cases reported in th Purpura fulminans (PF) is a rare, potentially fatal complication of disseminated intravascular coagulation that is commonly associated with severe bacterial infections such as those caused by the bacterium Neisseria meningitidis. With the advent of vaccination, meningococcal disease has become infrequent, with a reported incidence of 1 case per 100,000 people per year Agent: Neisseria meningitidis, a Gram-negative diplococcus. 2. Identification: a. Symptoms: Sudden onset of fever, head-ache, nausea, vomiting, lethargy, and irritability in cases of meningococcemia; headache, nausea, vomiting, and stiff neck in cases of meningitis. A petechial rash is seen frequently. Delirium and coma are not uncommon Factsheet. Meningococcal disease is caused by the bacterium Neisseria meningitidis. The bacterium is often detected in the nasopharynx without causing disease, a situation described as asymptomatic carriage. The bacteria occasionally invade the body and cause meningococcal infection, which is an acute severe bacterial infection Some antimicrobials, like vancomycin and nystatin are usually added to the Thayer-Martin agar, to inhibit the possible growth of undesired bacteria or fungi, and maximize the growth of Neisseria species. However, other Neisseria species, like N. meningitidis, have the same properties. So the maltose fermentation test is done to differentiate.

N. meningitidis is especially dangerous in young children. Typical symptoms are headache, meningeal signs, and fever. Mortality is close to 100% if untreated; less than 10% with prompt and appropriate antibiotic therapy. Effective vaccines targeting the polysaccharide capsules of major pathogenic strains (serogroups) are available Neisseria meningitidis causes meningitis in about 25 out of 100 people who get the illness every year in the United States. Neisseria meningitidis also can cause outbreaks of meningitis. Outbreaks are most common outside the U.S. If you are planning foreign travel, particularly to sub-Saharan Africa, talk with a doctor about getting the. The efficacy of ciprofloxacin to clear N. lactamica carriage is likely to similar as for N. meningitidis, as the organism is extremely sensitive to this antibiotic. Ciprofloxacin has been effective in clearing N. lactamica carriage within 24 hours in 100% of 4 individuals experimentally colonised in an ongoing human challenge study with wild. Journal of Medical Microbiology (2004), 53, 821-832 DOI 10.1099/jmm..45529- Review Neisseria meningitidis: an overview of the carriage state Siamak P. Yazdankhah1 and Dominique A. Caugant1,2 1 Correspondence Department of Airborne Infections, Division of Infectious Disease Control, Norwegian Institute of Siamak P. Yazdankhah Public Health, PO Box 4404 Nydalen, NO-0403 Oslo, Norway siamak. title = Neisseria meningitidis conjunctivitis in children, abstract = We examined two children from the same family who had purulent conjunctivitis. Isolates of Neisseria species were obtained from eye cultures and Gram stain of conjunctival scrapings disclosed many gram-negative intracellular diplococci

The Comprehensive Antibiotic Resistance Database gratefully acknowledges recent funding from the Genome Canada & Canadian Institutes of Health Research's Bioinformatics & Computational Biology program, allowing integration of the Antibiotic Resistance Ontology (ARO) with the Genomic Epidemiology Ontology, IRIDA platform, and OBO Foundry (see Genome Canada press release) Neisseria meningitidis is a bacterium hosted only by humans and is a leading cause of bacterial meningitis in the United States. This pathogen may also cause overwhelming sepsis, purpura fulminans, or (rarely) benign meningococcemia. Meningitis (inflammation of the membranes surrounding the brain and spinal cord) is a common form of. 7. Hedberg ST, Fredlund H, Nicholas P, Caugant DA, Olcen P, Unemo M. Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. Antimicrob Agents Chemother 2009;53(4):1561-1566. 8

Meningococcal Disease CD

Complement C5 inhibitor eculizumab has a great impact on the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). However, this treatment success has a major drawback: a substantially increased susceptibility for life-threatening Neisseria meningitidis infections. Therefore, N meningitidis vaccination is strongly advised before initiating complement C5-blocking therapy The bacterium Neisseria meningitidis, also called meningococcus, causes meningococcal meningitis. In children and teens , meningococcus is the most common cause of bacterial meningitis . In adults.

Antibiotics | Free Full-Text | Resistance to β-Lactams in

Neisseria Meningitidis - StatPearls - NCBI Bookshel

Bacteria or a virus can cause meningitis. Viral meningitis is more common, but bacterial meningitis is more serious. It can lead to brain damage, paralysis, or stroke. In some cases, it can be fatal. Many different types of bacteria can cause meningitis. Vaccines are available that target many of. Comparison ofsusceptibility ofNeisseria meningitidis to sodiumsulphadiazine andsodiumfusidate in vitro R. S. MILES ANDA. MOYES Fromthe DepartmentofBacteriology, University ofEdinburgh MedicalSchool, Edinburgh, UK suwmmARY Out of 100 strains of meningococci examined 62 were resistant to 1 mg/l or more o

Antibiotic sensitivities of Neisseria meningitidis

Topic Overview. Meningitis caused by Neisseria meningitidis is sometimes referred to as meningococcal disease.. Some people have Neisseria meningitidis in their throats without getting sick. But they can pass it to another person, who may get sick. Neisseria meningitidis also can cause outbreaks of meningitis. Outbreaks are most common outside North America Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly

Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6 R,7 R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[ Neisseria meningitidis or Streptococcus pneumoniae Neisseria meningitidis (meningococcus) is a human-restricted bacterium and a common coloniser of the nasopharynx. The bacterium is often harmless, but can in rare cases cause life-threatening meningitis and sepsis, commonly referred to as invasive meningococcal disease (IMD). Because of the rapid onset of disease and the risk of severe morbidity and mortality, antibiotics are administered.

Antibiotic resistant gonorrhea - wikidoc

Neisseria have a characteristic presence on Gram stain (Gram-negative diplococci) which can assist with discrimination, especially when antibiotics have been started prior to collection of specimens for bacterial culture. Laboratory Identification N. meningitidis is not difficult to identify in the laboratory and is typically diagnosed by isolatio Immunoprophylaxis. Vaccination is used for close contacts of patients with meningococcal disease due to A, C, Y, or W135 serogroups, to prevent secondary cases. [] Current meningococcal vaccines are indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis.MenHibrix, a combination vaccine, is a 4-dose sequence approved for use in children as. Neisseria meningitidis is a common cause of meningitis in young adults. Infected patients will present with the classic triad for meningitis: fever, stiff neck, and cognitive changes. Uniquely, this infection can cause the formation of a petechial or purpuric rash. About 20% of patients will progress to a meningococcal septicemia mostly caused by the lipooligosaccharid

A 68-year-old man presented with facial cellulitis and found to have Neisseria meningitidis bacteraemia with no evidence of infection outside of the facial soft tissue. He was treated with a course of intravenous ceftriaxone and transitioned to oral amoxicillin on discharge with significant improvement of his symptoms. N meningitidis is best recognised as a causal agent of bacterial meningitis Neisseria spp. (other than N. gonorrhoeae and N. meningitidis) MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Neisseria spp. (other than N. gonorrhoeae and N. Read Mor Neisseria meningitidis bacteremia cause DIC and pupura fulminans,which account for poor prognosis. A-24-year-old woman was admitted to our hospital complaining of fever, and pain with purpura of her limbs.Gram-negative cocci was recovered from the blood culture on admission, which was indentified a

Ninety-five patients in all age groups with clinical signs of meningitis and a turbid cerebrospinal fluid (CSF) sample were included in the study of isolates from 2002 to 2003. Seventy-one patients (74.7%) were confirmed as having Neisseria meningitidis either by culture ( n = 40) or by porA PCR ( n = 31) of their CSF Types of bacteria that can cause bacterial meningitis include Haemophilus influenzae (usually type b), Streptococcus pneumoniae, and Neisseria meningitidis. These bacteria can spread from person.

Modified Thayer-Martin Agar: Composition, preparationUS advisers back Cempra pneumonia antibioticPPT - Principles of antibiotic therapy in paediatricsBoy In Hospital Gown About To Get An Injection StockPrint Prokaryote Lab - Representative slides flashcardsPPT - Antibiotic Choices for Infections which Require

Update Thursday, May 3: According to Dr. Harry Lampiris of the VA, unvaccinated researchers at the lab had been working with several strains of Neisseria meningitidis, including serotype B, the strain believed to have killed the researcher now identified as Richard Din, 25, of San Francisco Neisseria gonorrhoeae (including beta-lactamase-positive and negative strains) Neisseria meningitidis Proteus mirabilis 2 Proteus vulgaris 2 Providencia rettgeri 2 Providencia stuartii 2 Serratia marcescens 2. 1 Enterococcus species may be intrinsically resistant to Cefotaxime In vivo studies have demonstrated an inverse relationship between carriage of commensal Neisseria lactamica and N. meningitidis (Deasy et al., 2015), whereas in vitro studies have revealed that some commensal Neisseria demonstrate potentially antagonistic effects against their pathogenic relatives (Custodio et al., 2020; Kim et al., 2019) Overview. Neisseria meningitidis, also simply known as meningococcus, is a gram-negative diplococcal bacterium best known for its role in meningitis. It only infects humans; there is no animal reservoir.It is the only form of bacterial meningitis known to cause epidemics.. Strains. There are many strains of meningococcus; the most clinically important are A, B, C, Y and W135 Prevalence of Neisseria meningitidis 16S rRNA mutation conferring resistance to spectinomycin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 221 important pathogens (see methodological details and complete list of analyzed pathogens).Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to. Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance Avril Brooks 1 , Jay Lucidarme 2 , Helen Campbell 3 , Laura Campbell 1 , Helen Fifer 4 , Steve Gray 2 , Gwenda Hughes 4 , Aiswarya Lekshmi 2 , Gabriel Schembri.