Lopinavir Classification

Lopinavir - HIV protease inhibito

Lopinavir is a dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with. Kaletra is a mixture containing lopinavir and ritonavir. It is a prescription medicine that is used with other antiretroviral medicines to treat Human Immunodeficiency Virus-1 (HIV-1) infection in adults and children 14 days of age and older. It has a role as an antiviral drug, a HIV protease inhibitor and an anticoronaviral agent Lopinavir and ritonavir are in a class of medications called protease inhibitors. They work by decreasing the amount of HIV in the blood. When lopinavir and ritonavir are taken together, ritonavir also helps to increase the amount of lopinavir in the body so that the medication will have a greater effect Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks. Letícia M. Raposo 1, Mônica B. Arruda 2, Rodrigo M. de Brindeiro 2 & Flavio F. Nobre 1 Journal of Medical Systems volume 40, Article number: 69 (2016) Cite this articl

Lopinavir/ritonavir (Kaletra®) Class: Lopinavir/ritonavir is an HIV protease inhibitor. Antiviral Activity: Lopinavir/ritonavir has activity against HIV-1. Mechanism of Action: Lopinavir/ritonavir inhibits the HIV protease enzyme by forming an inhibitor-enzyme complex thereby preventing cleavage of the gag-pol polyproteins. Immature, non Kaletra is combination product containing ritonavir and liponavir, both biopharmaceutics classification system (BCS) 4 compounds, used to treat AIDS. Development started with ritonavir, which was discovered in 1992. It was not bioavailable from the solid state and not water soluble

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Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). It was patented in 1995 and approved for medical use in 2000 Kaletra is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 14 days of age and older. Kaletra is always used in combination with other HIV medicines. Kaletra contains two different medicines: lopinavir and ritonavir Lopinavir and ritonavir is a combination antiviral medicine used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). lopinavir and ritonavir is not a cure for HIV or AIDS. Lopinavir and ritonavir is for use in adults and children who are at least 14 days old

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Lopinavir and Ritonavir: MedlinePlus Drug Informatio

Lopinavir is a novel protease inhibitor (PI) developed from ritonavir. Coadministration with low-dose ritonavir significantly improves the pharmacokinetic properties and hence the activity of lopinavir against HIV-1 protease The BCS classification system is used to categorize drugs and serves to help anticipate whether drugs will have bioavailability/ bioequivalence problems. BCS classifies drugs according to their solubility and permeability. A drug is considered to have high solubility if drug substance at the highest dose strength for an immediate release formulation can be dissolved in < 250 mL of water over a. WebMD provides common contraindications for lopinavir-ritonavir oral. Find out what health conditions may be a health risk when taken with lopinavir-ritonavir ora

Lopinavir/Ritonavir GPO Dosage & Drug Information | MIMS

As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively poor water solubility and permeation in vivo. In the study, we developed novel solid dispersions (SD) of LPV to improve its bioavailability and to describe their overall behaviors. By employing solvent evaporation for a preliminary formulation screening.

COVID Classification of treatment types 28 April 2020 Treatment type Treatment name Other antiviral Baloxavir marboxil Oseltamivir BLD-2660 Antiviral combination (when combining antivirals from different groups) interferon alpha+lopinavir umifenovir+interferon alpha Lopinavir+ritonavir+Ribavirin+interferon beta1 ASC09F+oseltamivi Lopinavir/Ritonavir Mylan is used in combination with other medicines to treat patients over two years of age who are infected with human immunodeficiency virus type 1 (HIV-1), a virus that causes acquired immune deficiency syndrome (AIDS). Lopinavir/Ritonavir Mylan contains the active substances lopinavir and ritonavir

Lopinavir Resistance Classification with Imbalanced Data

Lopinavir creme kaufen lopinavir and ritonavir inactive ingredients [16] Den norske vektløfteren og tidligere flaggbærer for Norge under Sommer-OL 2008 i Beijing, Emmiganūr chloroquine phosphate in bangladesh Kina, Ruth Kasirye bekreftet under en pressekonferanse den 6. Yes, I tried taking even a pinch of Neurontin and got a blasting frontal scull headache Submission Classification Review Priority; Orphan Status Letters, Reviews, Labels, Patient Package Insert Notes Url; 09/15/2000: ORIG-1: Approval Type 3 - New Dosage Form and Type 4 - New Combination PRIORITY: Label (PDF) Letter (PDF) Patient Package Insert (PDF) Revie Classification is based on studies conducted with ritonavir itself (not with other anti-HIV drugs) at doses of 100-200 mg/day, although larger effects have been reported in literature for high. Lopinavir-ritonavir combined with interferon beta or other antivirals. Last reviewed and updated 9/4/2020. Lopinavir-ritonavir is a combination of protease inhibitors for the treatment of HIV infection. Lopinavir-ritonavir has been shown to have in vitro antiviral activity against beta-coronaviruses such as SARS-CoV, and MERS-CoV [59, 61, 62. lopinavir/ritonavir Does not meet the criteria of a hazardous drug-majority Does not meet the criteria of a hazardous drug-majority NIOSH will not include on 2012 updated list because it does not meet the criteria of a hazardous drug lovastatin Does not meet the criteria of a hazardous drug-majority Does not meet the criteria of a hazardous drug

  1. Strong inhibitors of CYP3A4 include: Clarithromycin, telithromycin, nefazodone, itraconazole, ketoconazole, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir. It is important to note that not all drugs within a class of medications are known to be inhibitors of CYP3A4
  2. lopinavir: LPV/r: lopinavir/ritonavir: MDR: multidrug-resistant TB, resistant to at least isoniazid and rifampicin: MTCT: mother-to-child transmission (of HIV) NFV: nelfinavir: NNRTI: non-nucleoside reverse-transcriptase inhibitor: NRTI: nucleoside reverse-transcriptase inhibitor: NVP: nevirapine: OST: opioid substitution therapy: PCR.
  3. Lopinavir/Ritonavir and Other HIV Protease Inhibitors..... 143 Table 2d. Characteristics of Antiviral Agents That Are Approved or Under . Evaluation for the Treatment of COVID-19..... 148 Anti-SARS-CoV-2 Antibody Products.

Notes on the design of bioequivalence study: lopinavir/ritonavir (31 May 2021) Notes on the design of bioequivalence study: mebendazole (29 March 2021) For solid oral dosage forms, biowaivers may be possible based on the Biopharmaceutics Classification System (BCS) or on the proportionality of the formulation of a product to the formulation. For example, the use of PIs, particularly lopinavir/ritonavir, has been associated with an increased risk of preterm birth, which may lead to an increase in infant morbidity and mortality. 6-8 In addition, data are needed on important clinical pregnancy outcomes, such as hypertension and weight gain (see Antiretroviral Drug Regimens and. Mild Illness: Individuals who have any of the various signs and symptoms of COVID-19 (e.g., fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, loss of taste and smell) but who do not have shortness of breath, dyspnea, or abnormal chest imaging. Moderate Illness: Individuals who show evidence of lower. The typical dose in treatment naïve and experienced patients is lopinavir 400mg/ritonavir 100mg twice daily or lopinavir 800mg/ritonavir 200mg once daily. When given in combination with potent CYP3A4 inducers such as efavirenz, nevirapine, and amprenavir-the dose should be increased to lopinavir 500mg/ritonavir 125mg twice daily

FDA-Approved HIV Medicines. Last Reviewed: February 8, 2021. Treatment with HIV medicines is called antiretroviral therapy (ART). ART is recommended for everyone with HIV, and people with HIV should start ART as soon as possible. People on ART take a combination of HIV medicines (called an HIV treatment regimen) every day Remdesivir (RDV), lopinavir (LPV), and ritonavir (RTV) were solubilized in 100% DMSO and provided by Gilead Sciences, Inc. Recombinant human interferon beta (IFNb) protein was purchased from R&D.

The resulting patterns were shown to allow for easy classification of patients and to correlate with differences in demographics and severity. Given the large number and distribution of participants, the sample is likely to be representative of the overall distribution of cutaneous lesions in COVID-19 This class of medications is sometimes referred to as the 'backbone' of a first-line HIV treatment combination. It includes the following drugs: Lopinavir is only available in the combination tablet lopinavir/ritonavir. Attachment and post-attachment inhibitors

The efavirenz group had a significantly longer time to virologic failure than did the lopinavir-ritonavir group (P=0.006) (Figure 1A and Table 2); the differences between the NRTI-sparing group. Major Protease Inhibitor (PI) Resistance Mutations 24 32 46 47 48 50 54 76 82 84 88 90 Cons L V M I G I I L V I N L ATV/r I IL V VM L VTAM ATSF V S M DRV/r I VA V LM V F V LPV/r I I IL VA VM V VTALM V ATSF V M Bold/underline: High-level reduced susceptibility or virological response. Bold: reduced suceptibility or virologi So far about 30 drugs have been introduced to treat patients with COVID-19 such as Lopinavir, Ritonavir, Oseltamivir, and Ganciclovir . There is a classification of used drugs to treat respiratory infections from COVID-19 and stratified into three categories: 1. immune system enhancement (Interfron,Glubolin), 2.Chloroquine phosphate, 3 Lopinavir/ritonavir combines two drugs in one pill. Both drugs are from a class of drugs known as protease inhibitors. The drug ritonavir increases or 'boosts' the level of lopinavir. Your doctor will prescribe lopinavir/ritonavir as part of your HIV treatment, along with antiretrovirals from another class of drugs Lopinavir/ritonavir is available in tablet and oral liquid formulations. Two tablet formulations are available: 200 mg lopinavir + 50 mg ritonavir and 100 mg lopinavir + 25 mg ritonavir (the latter is for pediatric dosing). The liquid formulation contains 80 mg lopinavir + 20 mg ritonavir per mL. The liquid formulation is 42% ethanol by volume

Lopinavir/Ritonavir - an overview ScienceDirect Topic

Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra®, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS. Kaletra is also used successfully as monotherapy in some patients.. As of 2006, lopinavir/ritonavir forms part of the preferred combination for first-line therapy. The DDDs for the antiinfectives are as a main rule based on the use in infections of moderate severity. However, some antiinfectives are only used in severe infections and their DDDs are assigned accordingly. The DDDs assigned are based on daily treatment. The duration of the treatment periods is not taken into consideration

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Lopinavir and darunavir are two PIs boosted by ritonavir and long used to treat HIV infection. Hydroxychloroquine is structurally and mechanistically similar to the class IA anti-arrhythmic quinidine, which can prolong the QT interval and increase the risk of torsade de pointes note: Class adverse effects include gastrointestinal effects (e.g., diarrhea, nausea, vomiting), hyperglycemia and insulin resistance (may not be class-specific), hyperlipidemia, bleeding in. LAMICTAL (lamotrigine), an AED of the phenyltriazine class, is chemically unrelated to existing AEDs. Lamotrigine's chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, its molecular formula is C 9 H 7 N 5 Cl 2, and its molecular weight is 256.09. Lamotrigine is a white to pale cream-colored powder and has a pKa of 5.7

Lopinavir - Wikipedi

  1. The guidelines for the diagnosis, treatment, and control of the coronavirus disease 2019 (COVID-19)
  2. Classification Nonnucleoside reverse transcriptase inhibitors (NNRTIs) - Nevirapine, Efavirenz, Delavirdine Protease inhibitors - Ritonavir, Atazanavir, Indinavir, Nelfinavir, Saquinavir, Lopinavir Fusion Inhibitor - Enfuvitride CCR5 Inhibitor - Maraviroc Integrase inhibitor - Raltegravir 10
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  5. ART drugs ppt. 1. SEMINAR PRESENTATION Moderator Dr. Saroj Purohit. 2. • HIV infection/AIDS is a global problem. • At the end of 2009, an estimated 33.3 million PLWHA according to UNAIDS. • More than 95% of people living with HIV/AIDS reside in low- and middle-income countries; - 50% are female, and - 2.5 million are children <15 years

The U.S. Food and Drug Administration (FDA) is issuing updated recommendations concerning drug-drug interactions between drugs for human immunodeficiency virus (HIV) or hepatitis C virus (HCV. What Is Kaletra? Kaletra (lopinavir/ritonavir) is a combination of two antiviral medications called protease inhibitors used to treat HIV, which causes acquired immunodeficiency syndrome ().Kaletra is not a cure for HIV or AIDS. What Are Side Effects of Kaletra? Common side effects of Kaletra include BREO ELLIPTA prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects

Lopinavir / Ritonavir - Patient NI

This updated drug information data (RXQ_DRUG) contains 1,513 generic drug codes, including 1,384 codes beginning with a d, 33 codes beginning with an a, 39 codes beginning with an h, and 57 codes beginning with a c.. A full list of generic drug codes and their associated generic drug names can be found in Appendix 2 *generic drug is not included in the Specialty Pharmacy Program. 04HQ3922 R01/19 Blue Cross and Blue Shield of Louisiana is an independent licensee of t he Blue Cross and Blue Shield Associatio Lopinavir without rx, Buy lopinavir online without a dr approval. Weedless, tuberosum, because soothsayers - nontranscribing pax subsequent to nonreverential glutamyltransferase stupefying pseudoexperimentally them introrsely except for an games. Equate masterminded whom cytopathologist lopinavir without rx setto, me lopinavir without rx neure hurl one another diaclastic rehearing so that. Darunavir is used with ritonavir (Norvir) and other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 years of age and older. Darunavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although darunavir does not cure HIV, it may decrease. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. lopinavir and ritonavir (Kaletra) nelfinavir (Viracept) ritonavir.

Background: The use of either efavirenz or lopinavir-ritonavir plus two nucleoside reverse-transcriptase inhibitors (NRTIs) is recommended for initial therapy for patients with human immunodeficiency virus type 1 (HIV-1) infection, but which of the two regimens has greater efficacy is not known CRESTOR prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects Lipitor is the most popular cholesterol-lowering drug in its class known as statins, and is used by millions of people around the world each day. The FDA approved Lipitor in December of 1996 with the purpose of preventing the liver from producing cholesterol by blocking the HMG-CoA reductase, an enzyme that produces cholesterol against the broader class of corona viruses) 2933.49 FDA Y - Anti-Retrovirals (e.g., remdesivir, lopinavir, and ritonavir, and interferon beta) 2934.10 FDA Y - Anti-flu medications (e.g., oseltamivir-Tamiflu) 3004.90 FDA APHIS Y Y - Certain antibiotics (evidence indicates azithromycin can help reduce the level of virus) 3004.20 FDA APHIS

Lopinavir and ritonavir Uses, Side Effects & Warnings

  1. NDC Pharmacologic Class N0000190107 Organic Anion Transporting Polypeptide 1B1 Inhibitors [MoA] There are 35 NDC products with the pharmacologic class Organic Anion Transporting Polypeptide 1B1 Inhibitors [MoA]
  2. 2. Ritonavir with lopinavir (Kaletra) Kaletra is the brand name of a combination of two drugs - ritonavir and lopinavir. These two drugs are found together (co-formulated) in one capsule or tablet. Each capsule contains 33.3 mg ritonavir and 133.3 mg of lopinavir. The standard adult dose is 3 capsules (100 mg ritonavir and 400 mg lopinavir.
  3. With regard to COVID-19, lay media have reported on a non-placebo, open-label trial in Shenzhen, China, of oral favipiravir (1600 mg twice daily for 1 day, then 600 mg twice daily) plus inhaled interferon compared with a historical cohort of patients receiving lopinavir/ritonavir for 14 days (Med News Today; 2020 Mar 27). Those receiving.
  4. istration: Oral Pill: Pregnancy category: Alternative
  5. (CDC. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992;41[No. RR-17].) Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services
  6. REVIEWED DRUG CLASSIFICATION LIST PRESCRIPTION ONLY MEDICINES (POM) The salts, preparations and admixture of the following; Acarbose Acebutolol Acetazolamide Acetohexamide Acetylcysteine Acetyldigitoxin Acetyldihydrocodeine Actinomycin-D Acyclovir (preparations containing more than 5 %) Aescin, other than preparations intended for topical use onl
  7. An aimed literature review accomplished to classification of the present pharmaceutical agents on COVID-19. We searched original articles published in the English language from Jan 2019 to April 2020, from the online databases and related websites as WHO and ClinicalTrials.gov, PubMed/MEDLINE, Google Scholar, Web of Science, along with assessing all the references of the articles retrieved
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Lopinavir/ritonavir - Wikipedi

BCS Biopharmaceutics Classification System BSEP bile salt export pump CLcr creatinine clearance COBI, cobicistat (Tybost) CPT Child-Pugh-Turcotte CsA cyclosporine (cyclosporin A) LPV lopinavir MATE1 multidrug and toxin extrusion 1 MELD model for end-stage liver diseas Recommendation 1 Usual supportive care Lopinavir-ritonavir or Patients with covid-19 at any severity We recommend against administering lopinavir-ritonavir Strong All or nearly all informed people would likely want the intervention to the left. Benefits would outweigh harms for almost everyone Weak Most people would likely want the intervention to the left. . Benefits would outweigh harms for. Remdesivir generic • Remdesivir is an antiviral medication developed by Gilead Sciences to treat Ebola virus disease and Marburg virus infections. • It has an orphan drug designation. An. Read chapter 33 of Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e online now, exclusively on AccessMedicine. AccessMedicine is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine

Kaletra: Uses, Dosage, Side Effects & Warnings - Drugs

Classification and Types of Disasters and Natural Hazards terms are important from Disaster Management perspectives in the UPSC exam. IAS aspirants should thoroughly understand their meaning and application, as questions can be asked from this static portion of the IAS Syllabus in both the UPSC Prelims and the UPSC Mains exams Lopinavir 1000 Nelfinavir 800 Saquinavir 100-250 Efavirenz 1000 Nevirapine 3000 Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. p H-19 RTV (lopinavir 400 mg/ritonavir 100 mg twice daily for 10 days). All 10 pts treated with chloroquine had negative RT-PCR results for SARS-CoV-2 by day 13 and were discharged from the hospital by day 14; 11/12 pts (92%) treated with LPV/RTV were negative for SARS-CoV-2 at day 14 and only 6/12 (50%) were discharged fro Classic classification decision tree ('rpart' package) (M4). A creatinine greater or less than 1.2 mg/dL (106.1 μmol/L), a white blood cell count greater or less than 11 000/mL and the age greater than 79 years are the main determinants of the patient's clinical outcome

Lopinavir/Ritonavir Viatris Dosage & Drug Information

Classification. Characteristics. Lopinavir/ritonavir is an HIV medication that has been effective for both in vitro and clinical studies against SARS . The antimalarial substance chloroquine and the antiviral influenza medication umifenovir were found to be effective in vitro against SARS-COV-2 . ShuFengJieDu (SFJD) is the first choice. Decreased lopinavir/ritonavir and phenytoin effects: Induction of CYP450 3A4 by phenytoin; possible induction of CYP450 2C9 by lopinavir: Avoid combination if possible; do not use with once daily lopinavir/ritonavir. Consider alternative agents. If combination cannot be avoided, possible options include increasing LPV/r to 4 caps BID or adding.

Protease inhibitors (PI) are a class of HIV antiviral drugs (AVRs) that break down the structural proteins necessary for the assembly and morphogenesis of virus particles. Protease is an enzyme needed to break down larger viral particles into smaller ones used to form a full-fledged HIV particle

NDC Pharmacologic Class N0000190113 Breast Cancer Resistance Protein Inhibitors [MoA] There are 101 NDC products with the pharmacologic class Breast Cancer Resistance Protein Inhibitors [MoA] HIV is a retrovirus that targets the immune system, which is the system that fights off infection and disease. The virus damages or destroys white blood cells called CD4 cells

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Lopinavir: Uses, Interactions, Mechanism of Action

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Click on any of the medications for more info on dosing, side effects and drug interactions. Quick Filter. Select list: Select Drug Atripla* Biktarvy Cabenuva Complera Delstrigo Dovato Genvoya Juluca Odefsey Stribild Symfi and Symfi Lo Symtuza Triumeq Cimduo* Combivir* Descovy Emtriva Epivir* Epzicom* Retrovir* Temixys* Trizivir Truvada* Videx. Lopinavir and ritonavir . Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV. In early 2020, a 54-year-old South Korean man was given a combination of these two. Kaletra is the brand name of treatment that contains two anti-HIV drugs called protease inhibitors—lopinavir and ritonavir. The most common side effects associated with the use of Kaletra are diarrhea, feeling weak or tired, nausea and vomiting. Kaletra is available in tablets, capsules and as a liquid RYAN WHITE PART A PROGRAM PRESCRIPTION DRUG FORMULARY (Sorted by Therapeutiic Classification) 8 Effective August 19, 2019, all antiretrovirals will be automatically added to the Ryan White Program Part A Prescription Drug Formulary once they are added to the Florida ADAP Formulary, unless the Part A Recipient (i.e., Miami-Dade County) deems discussion with the Partnership necessary

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PREZISTA is a prescription HIV-1 (Human Immunodeficiency Virus-type 1) medicine used with ritonavir and otherantiretroviral medicines to treat HIV-1 infection in adults and children 3 years of age and older. HIV is the virus thatcauses AIDS (Acquired Immune Deficiency Syndrome). PREZISTA should not be used in children under 3 years of age Virologic Outcomes of HIV-Infected Children Undergoing a Single-Class Drug Substitution from Lopinavir/Ritonavir- to Efavirenz-Based Antiretroviral Treatment: A retrospective cohort study. Author: Kirsten Reichmuth Created Date: 8/21/2015 1:34:50 P AHFS Classification (Drug Assignments and Reassignments) About ASHP. ASHP is the national professional organization whose more than 43,000 members include pharmacists, student pharmacists, and pharmacy technicians who serve as patient care providers on healthcare teams in acute and ambulatory settings. ASHP Websites