Perianal disease SlideShare

ANAL & PERIANAL DISEASE (PART 1) 1. SHAHIRAH ALIYA BINTI ABD KAMAL 63. 2. INTRODUCTION • The length of the anal canal is about 4 cm (range, 3-5 cm), • 2/3rd of this being above the dentate line • 1/3rd below the dentate line. 3 ANAL FISSURE (SYN:FISSURE-IN- ANO) A longitudinal split in the anoderm of the distal anal canal, which extends from the anal verge proximally towards, but not beyond the dentate line. 24. • Superficial, small but distressing lesion • Fissure ends below the dentate line • Commonly occurs in the midline, posteriorly or anteriorly. 25 anal & perianal disease (part 2) 1. anal & perianal disease (part 2) nur hanisah binti zainoren 2. contents anal fissure pruritus ani anorectal abscess fistula-in-ano hidradenitis suppurativa anal warts anal intraepithelial neoplasia (ani) anal stenosis malignant tumors 3 Crohn's Disease • incidence of perianal complications-22 -54% • Anorectal abscess - drainage. • A simple fistula in a patient with a normal rectum -primary fistulotomy . • Complex fistulas in patients with active rectal Crohn's disease remain a therapeutic challenge. These cases are better served with prolonged drainage 36


  1. Anorectal diseases. 1. Done BY : Sara Al-Ghanem | 208009915Supervised BY: Dr. M. Yasser 1. 2. To understand surgical anatomy of anus and rectum in relationto surgical disease and treatment To understand the pathology, CF, investigations, D/Ds andtreatment To appreciate that ano-rectal disease is common and conservativetreatment may be.
  2. al ileum
  3. PowerPoint is the world's most popular presentation software which can let you create professional Perianal abscess & pilonidal disease powerpoint presentation easily and in no time. This helps you give your presentation on Perianal abscess & pilonidal disease in a conference, a school lecture, a business proposal, in a webinar and business and professional representations
  4. Title: Perianal abscess & pilonidal disease Author: Rajeev Last modified by: snoopy Created Date: 11/16/2004 8:34:56 PM Document presentation format - A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 58c3b6-MWI3
  5. Introduction Perianal disease (PD; uncomplicated abscess and/or fistula) is a relatively common condition. There is a recognised association with Crohn's disease (CD) and 11-26% of patients in paediatric[1][1] and adult[2][2] case series are purported to develop intestinal CD. However, the temporal relationship is unclear, as is the natural history of PD

Anal and perianal diseases - SlideShar


Perianal abscess fistula in ano - SlideShar

Chronic diarrhea is defined as an increase in the frequency (more than 2 bowel movements per day) and fluidity of stools for more than 4 weeks duration. It can be divided as watery, fatty or inflammatory according to the stool characteristics. . Mechanisms of Diarrhea Peritoneal cancer is a rare cancer. It develops in a thin layer of tissue that lines the abdomen.It also covers the uterus, bladder, and rectum.Made of epithelial cells, this structure is called. Crohn disease (CD) is the most common cause of perianal granulomatous disease in Western nations. [1, 2] Elsewhere, the incidence of non-CD perianal granuloma varies, but it may be more common than in the United States

Crohn disease is a chronic inflammatory condition that can affect any part of the gastrointestinal tract, from the oral cavity to the anus. Perianal manifestations of Crohn disease include perianal fistula, perianal abscess, anal canal lesions (anal fissures and anal stricture). Symptoms can vary from rectal pain and perianal discharge to. Perianal dermatitis is a disease manifested in the form of inflammation of the skin in the area around the anus. Perianal dermatitis, the symptoms of which are accompanied by swelling, pruritus and pronounced redness, are often allergic, contact, fungal or bacterial, arising from inflammatory diseases that are relevant to the intestine, hemorrhoids, enterobiasis or anal fissures

Perianal activity often parallels abdominal disease activity, but it may occasionally be the primary site of active disease. Anal fistulas can also be associated with diverticulitis , foreign-body reactions, actinomycosis , chlamydia , lymphogranuloma venereum (LGV), syphilis, tuberculosis, [ 3 ] radiation exposure, and HIV disease Crohn's Disease - Slowly progressive; colicky pain, malaise; fistula formation (sigmoidoscopy, anal fissure assessed), possible abdominal abscess formation or intestinal obstruction (evidence by abdominal pain); rectal bleeding (objective with exam); reduced appetite and weight loss (15 lbs); inflammatory process (reddened, tender lymph nodes); family history (mother & brother); perianal.

Genital ulcer disease (GUD) is a general term that usually refers to lesions caused by specific sexually transmitted infections (STIs). Although GUD is common throughout the world, the specific causes vary widely by geographic region. Genital herpes, syphilis, and chancroid lead the differential diagnosis, but conditions unrelated to STIs. Perianal suppuration- Abscess & Fistula Dr Pankaj Kumar Assistant Professor Surgical Gastroenterolog Perianal Fistula 31. Mechanism of Perianal Fistula 32. Carcinoma in Crohn's Disease 33. Acute Inflammatory Presentation 34. Chronic Inflammatory Presentation 35. Scarring and Narrowing 36. Enteroenteric Fistula 37. Enterovesical Fistula 38. Localised Phlegmon 39. Presentation 40 A perianal fistula (fistula-in-ano) refers to an abnormal connection between the anal canal and the perianal skin.. The majority are associated with anorectal abscess formation, with one third of patients with an anorectal abscess having an associated perianal fistula at the time of presentation.. Aetiology. The formation of an perianal fistula typically occurs as a consequence of an perianal. Perianal Paget disease is an intraepithelial adenocarcinoma and can be associated with underlying colorectal adenocarcinoma and anal carcinoma in 38%-69% of patients . Perianal Paget disease is associated with nonspecific symptoms such as perianal pain, bleeding, and itching; and the nonspecific symptoms frequently delay the diagnosis

Anorectal diseases - SlideShar

Pyoderma gangrenosum (pie-o-DUR-muh gang-ruh-NO-sum) is a rare condition that causes large, painful sores (ulcers) to develop on your skin, most often on your legs. The exact causes of pyoderma gangrenosum are unknown, but it appears to be a disorder of the immune system. People who have certain underlying conditions, such as inflammatory bowel. Pilonidal disease is a chronic skin infection in the crease of the buttocks near the coccyx (tailbone). It affects about 70,000 people in the US annually and is more common in men than women. Most often it occurs between puberty and age 40 Streptococcal perianal disease in children. Pediatrics. 1987;80:659-63. 14. Brook I. Microbiology of perianal cellulitis in children: comparison of skin swabs and needle aspiration. Int J.

Dyschezia, Perianal Abscess, Negated. None. Unsure. None. Possible Causes. Anorectal Fistula. In addition, the long-term non-healing anal fistula can also cause anorectal stenosis, dyschezia, anemia, weight loss, listlessness, neurasthenia and other symptoms. [english.zryhyy.com.cn] The most common type is a perianal abscess (60% of cases. Galandiuk S, Kimberling J, Al-Mishlab TG, Stromberg AJ. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg. 2005 May. 241 (5):796-801; discussion 801-2. . . Guidi L, Ratto C, Semeraro S, Roberto I, De Vitis I, Papa A, et al. Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn's disease. The stage of the hemorrhoidal disease was II (10 patients), III (3), and IV (1). This treatment was decided by a multidisciplinary team (proctologist, visceral surgeon, and radiologist). Seven patients underwent previous proctological surgery. Ten patients had coagulation disorders (anticoagulants or cirrhosis)

Perianal-abscess & Valitutti Symptom Checker: Possible causes include Inflammatory Bowel Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search Overview. Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes blood vessel inflammation throughout your body. The disease can lead to numerous signs and symptoms that can seem unrelated at first. They can include mouth sores, eye inflammation, skin rashes and lesions, and genital sores The presence of a granuloma on rectal biopsy or perianal disease such as fissure or tags was considered suggestive of Crohn's disease and excluded a diagnosis of ulcerative [journals.lww.com] Abdominal Visceral Abscess. For example, a perianal PERIANAL ABSCESS 10. [slideshare.net

Perianal fistula. A perianal fistula is an abnormal connection between the epithilialised surface of the anal canal and the skin. The causes of perianal fistulas: Primary. Obstruction of anal gland which leads to stasis and infection with absces and fistula formation (most common cause). Secondary Crohn's disease is also more likely than ulcerative colitis to cause fistula, benign fibrous strictures, and perianal disease. Despite these differences, in about 10% of patients with chronic inflammatory bowel disease confined to the colon both macroscopically and microscopically, the diagnosi A normal hemorrhoid, if it's visible on the exterior, will look like a rubbery lump and won't have the dark blue coloration. Symptoms of thrombosed hemorrhoids include: 3 . Pain when sitting, walking, or defecating. Bleeding when defecating. Itching around the anus A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Gut. 2014 Sep. 63(9):1381-92. . . Nelson RL, Thomas K, Morgan J, Jones. We are open for safe in-person care. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information Latest on COVID-19 vaccination by site: Arizona patient vaccination updates Arizona, Florida patient vaccination updates Florida, Rochester patient vaccination updates Rochester and Mayo Clinic Health System.

Bowen's disease is a very early form of skin cancer that's easily treatable. The main sign is a red, scaly patch on the skin. It affects the squamous cells, which are in the outermost layer of skin, and is sometimes referred to as squamous cell carcinoma in situ Epidemiology. Incidence is estimated at ~1:10,000 1, with a recognized male predilection of 2-4:1.. Associations. spontaneous. diverticulitis: perhaps the most common cause in developed countries; Crohn disease. it is unclear if ulcerative colitis is a risk factor for perianal disease 11; other bowel or pelvic infection Laser closure of the perianal fistula is the minimally invasive and low complication rate procedure which is a life-saving way for complex fistulas, preserving anal sphincter injury. Unfortunately, wide range success rate reported before (30-80%), the investigators are searching to reach better rates. Internal closure of the fistula orifice.

de la Portilla F, Alba F, Garcia-Olmo D, et al. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis. 2013 Mar. 28(3):313-23. Crohn's disease. The second most common cause of rectovaginal fistulas, Crohn's disease is an inflammatory bowel disease in which the digestive tract lining is inflamed. Most women with Crohn's disease never develop a rectovaginal fistula, but having Crohn's disease does increase your risk of the condition Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 July 2021), Cerner Multum™ (updated 1 July 2021), ASHP (updated 30 June. Crohn's disease (CD) is a chronic inflammatory bowel disease of unknown origin characterized by periods of remission and exacerbation. It can occur anywhere along the gastrointestinal tract from the mouth to the anus, but most commonly CD affects the distal small intestine and the proximal large colon (McCance & Huether, 2014) Gastrointestinal Hemorrhage & Perianal Abscess Symptom Checker: Possible causes include Inflammatory Bowel Disease Type 1. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search

Crohn\'s disease - SlideShar

Chronic Fatigue Syndrome & Diarrhea & Perianal Ulcer Symptom Checker: Possible causes include Inflammatory Bowel Disease Type 1. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search An abscess is a localized collection of pus in a hollow area formed by the breaking up of tissues. A renal abscess is one that is confined to the kidney and is caused either by bacteria from an infection traveling to the kidneys through the bloodstream or by a urinary tract infection traveling to the kidney and then spreading to the kidney tissue Crohn disease is a chronic transmural inflammatory bowel disease that usually affects the distal ileum and colon but may occur in any part of the gastrointestinal tract. Symptoms include diarrhea and abdominal pain. Abscesses, internal and external fistulas, and bowel obstruction may arise. Extraintestinal symptoms, particularly arthritis, may.

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  1. Severe perianal disease, rectal sparing, absence of bleeding, and asymmetric or segmental involvement of the colon indicate Crohn disease rather than ulcerative colitis. Colonoscopy is usually unnecessary initially but should be done electively if inflammation has extended proximal to the reach of the sigmoidoscope
  2. A periodontal abscess is a collection of pus that occurs in the tooth-supporting tissues (the periodontium) as a result of bacterial infection. It usually occurs as a complication of advanced gum disease (periodontitis), which is caused by poor oral hygiene. The periodontal abscess causes pain that becomes worse with biting on the affected tooth
  3. Perianal Abscess & Recurrent Diarrhea & Weight Loss Symptom Checker: Possible causes include Inflammatory Bowel Disease Type 1. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search

Patients with perianal disease, stricturing or penetrating behaviour, or severe growth retardation should be considered for up-front anti-tumour necrosis factor [TNF] agents in combination with an immunomodulator. Therapeutic drug monitoring to guide treatment changes is recommended over empirically escalating anti-TNF dose or switching therapies History of Present Illness. L.S. is a 16 Y.O. Caucasian male who was referred to the gastrointestinal (GI) clinic by his pediatrician. The patient complains of abdominal pain, diarrhea, and fatigue for the past two months. The patient's mother reports that he has not been eating and has been losing weight. She states that he can be a picky. The white matter at the cord's periphery contains ascending and descending tracts of myelinated sensory and motor nerve fibers. The central H-shaped gray matter is composed of cell bodies and nonmyelinated fibers (see figure Spinal nerve).The anterior (ventral) horns of the H contain lower motor neurons, which receive impulses from the motor cortex via the descending corticospinal. Pus is formed following infection of soft tissue around kidney or infection of peripheral kidney tissue. Renal abscess is an uncommon disease caused by trauma and infection associated with kidney stone. In this article, we will discuss in detail about the causes, symptoms, and treatments of Renal Abscess

PPT - Perianal abscess PowerPoint presentation free to

Antibiotics have been used off-label to treat infections associated with IBD, specifically in patients with fistulas, abscesses, pouchitis, postsurgical CD resection, or perianal disease. 13,14,16,52 It is possible that microorganisms may be a contributing factor to the pathogenesis of CD. 52,53 However, evidence to support the use of. Sometimes the disease is found by accident when one of these tests is done for another reason. X-rays are used to make the final diagnosis. X-rays. In x-ray images, bones affected by Paget's disease have a particular appearance that is different from other bones. Accordingly, a doctor will use x-rays, alone or with a blood test or bone scan. Hirschsprung disease occurs in about 1 out of 5,000 live births. It is three times more common in boys than girls. About 12% of cases are linked to a genetic disorder. This is most often Down syndrome or a rare condition called Mowat-Wilson syndrome. About 80% of people with the disease do not have a family history of the disease Suspicion of anal stenosis is heightened by a history of hemorrhoidectomy, Crohn's disease, or excessive laxative use. Physical examination confirms the diagnosis. Visual examination of the anal canal and perianal skin, along with a digital rectal examination, is usually suffice to establish the presence of anal stenosis

The natural history of perianal disease Gu

  1. Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years
  2. In Pakistan, few patients have perianal or fistulizing disease. In India, the age at presentation of CD is a decade later than in the West, colonic involvement is more common, and fistulization appears to be less common. Tuberculosis is an important differential-diagnostic issue in developing countries. Numerous genetic loci have been.
  3. Anal fissures are tears, or cracks, in your anus. Fissures are sometimes confused with hemorrhoids. These are inflamed blood vessels in, or just outside, the anus. Both fissures and hemorrhoids often result from passing hard stool. Fissures result from the stretching of your anal mucosa beyond its.

Diagnosis and Treatment of Perianal Crohn Disease

#### Summary points Anal fistula is part of the spectrum of perianal sepsis. It is a chronic condition that may present de novo or after an acute anorectal abscess. Anal fistula causes a variety of prolonged or intermittent symptoms including pain, discharge, and social embarrassment. The goals of management are to eradicate the fistula and prevent recurrence while maintaining continence were initially classified as cutaneous lesions, such as Bowen disease and carcinoma in situ. Over time, a causal relationship was established between anal dysplasia and HPV perianal infection. However, terminologies of squamous precancerous lesions of anal canal continued to be diverse. The WHO classification (Box 1), for instance Candidiasis is a fungal infection due to any type of Candida (a type of yeast). When it affects the mouth, in some countries it is commonly called thrush. Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. Other symptoms may include soreness and problems swallowing. When it affects the vagina, it may be referred to as a yeast infection or thrush Pyoderma gangrenosum is an uncommon disease that affects males and females of any age but is more common in those aged over 50 years. It is thought to be a reaction to an internal disease or condition. Known associations include: Inflammatory bowel disease (ulcerative colitis and Crohn disease) Rheumatoid arthritis

Anal Fistula: Causes, Symptoms, Diagnosis & Treatmen

Erosive lichen planus is a destructive autoimmune disease of unknown cause involving T lymphocytes. Occasionally, it is drug-induced and will resolve on withdrawal of the responsible drug. Partial response to antifungal agents and antibiotics indicates an abnormal response to local microflora may be involved, especially Candida albicans Bulbocavernosus reflex. The bulbocavernosus reflex (BCR) is an oligosynaptic sacral reflex that can be used to assess the integrity of sacral sensory and motor fibers as well as the sacral spinal cord segments, S2-S4. Intraoperatively, repetitive stimulation of the dorsal penile or clitoral nerve generates an EMG response obtained from hooked. Crohn's Disease. Crohn's disease is a chronic inflammatory disease of the digestive tract. Symptoms include abdominal pain and diarrhea, sometimes bloody, and weight loss Stitches can usually be removed within 7 to 10 days of.Swimming after a perianal abscess Scrotal abscess perianal abscess Download Here Free HealthCareMagic App to Ask a Doctor. All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice

A skin lesion is a part of the skin that has an abnormal appearance compared to the skin around it. Discover 21 types of skin lesions, like acne and eczema Most common causes are Crohn's disease (complex fistulae with irregular edges), infections (tuberculosis [lung disease usually present] and lymphogranuloma venereum) and rectal foreign bodies Uncommon causes are actinomycosis (rare perianal manifestation, mostly in immunocompromised hosts, Dis Colon Rectum 2005;48:575 , Proc R Soc Med 1970;63.

Common Anorectal Disorder

  1. disease = 78% - Indications are limited to complications Obstruction Perforation, fistula, abscess GI bleeding Cancer Perianal disease - Resection of the complicated segment only - ignore gross disease - ? Laparascopic surger
  2. Symptoms. Symptoms of Crohn's vary widely depending on the person and on the part of the gastrointestinal tract, or GI tract, that the disease attacks. In the lower GI tract, or colon, common.
  3. The Strongyloides stercoralis life cycle is complex, alternating between free-living and parasitic cycles and involving autoinfection.In the free-living cycle: Rhabditiform larvae are passed in the stool of an infected definitive host , develop into either infective filariform larvae (direct development) or free-living adult males and females that mate and produce eggs , from which.
  4. Parasitic infections of the lung occur worldwide among both immunocompetent and immunocompromised patients and may affect the respiratory system in a variety of ways. This review provides an update on the presenting symptoms, signs, investigation and management of diseases affecting the lung caused by protozoa, nematodes and trematodes. The clinical presentations and radiographic findings of.
  5. Perianal disease. This often involves fistulas, or abnormal connections between tissues, deep tissue infections, as well as sores and ulcers on the outer skin around the anus
  6. Bladder fistula is most often treated with surgery to remove the damaged part of the bladder. Healthy tissue is moved between the bladder and the other organ to block the opening. If the fistula is caused by a disease, such as colon cancer or inflammatory disease, the fistula is fixed during the surgery to treat that disease
  7. al ileum. Surgery is usually carried out when badly affected parts of the bowel have caused an abscess or fistula in the abdomen or in the perianal area

Vitiligo PowerPoint Presentation (PPTs

matous disease (and of other phagocytic disorders) include recurrent pyogenic or fungal skin infections, or abscesses. Infec- birth), or erosive perianal ulcers, can be early signs o Crohn's disease is more likely in those with a strong family history (first-degree relative affected, ie parent, brother or sister) and in people who smoke. Infections (especially upper respiratory and bowel infections) ot taking non-steroidal anti-inflammatory drugs (NSAIDs) can also aggravate symptoms

Anal Fistula: Symptoms, Causes, Diagnosis, Treatmen

Persistent or recurrent disease can be treated with radical surgical resection (eg, abdominoperineal resection [APR]). This procedure involves removal of the anus, the rectum, and a portion of the perineum, as well as creation of a permanent colostomy. For perianal SCC, wide local excision (shown) is the treatment of choice About 30% of children and adolescents develop perianal disease, which affects the area around the anus. This can make it painful for children to go to the bathroom. Affected individuals may develop fissures or tears, abscesses, or a fistula in the perianal region. A fistula is a small, abnormal passageway that connects the skin to the inside of.

Anal Itching (Pruritus Ani): Types, Causes, Diagnosis

Crohn disease is an idiopathic, chronic inflammatory process that can affect any part of the gastrointestinal tract from the mouth to the anus (see the image below). Individuals with this condition often experience periods of symptomatic relapse and remission The phenotypic classification of Crohn's disease was amended accordingly, and this culminated in the now generally used Montreal criteria, which include perianal disease and age at disease onset.4 Data in a prospectively followed cohort from 1995 to 2009 (reported in this issue of GUT by the same group of investigators in Paris), seemingly.

MR Imaging Evaluation of Perianal Fistulas: Spectrum of

Perianal Crohn Disease Impression Statements. Perianal fistulas generally arise from the rectum or anal canal secondary to deep mucosal ulceration and active inflammation and can extend to the skin surface or any other adjacent epithelial-lined surface (eg, vagina or urethra) . These fistulas do not arise from bowel strictures, as do internal. Adults: The adult louse is about the size of a sesame seed, has 6 legs (each with claws), and is tan to grayish-white . In persons with dark hair, the adult louse will appear darker. Females are usually larger than males and can lay up to 8 nits per day. Adult lice can live up to 30 days on a person's head Joint Pathology Center Veterinary Pathology Services Wednesday Slide Conference 2017-2018 Conference 25 May 9 th, 2018. CASE IV: Case 2 (JPC 4101147) Signalment: 3.5-month-old, female, CyBB knockout (Mus musculus), mouse. History: The animal had been used as a breeder and was found dead. Dystocia was the top differential diagnosis

Some people who have a colostomy or ileostomy to remove stool from their body will live with it for life. Others may have a temporary ostomy while they recover from surgery.. Or you may be eager. Crohn's disease may appear anywhere along the gastrointestinal tract, from the mouth to the rectum. X-rays and other images can help identify the severity and location of Crohn's disease. These. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg. 2005 May. 241 (5):796-801; discussion 801-2. . . Giordano P, Gravante G, Sorge R, Ovens L, Nastro P. Long-term outcomes of stapled hemorrhoidopexy vs conventional hemorrhoidectomy: a meta-analysis of randomized controlled trials. Arch Surg. 2009 Mar. It is a slowly progressive, destructive, inflammatory disease that may affect any organ. The three most common forms are neurosyphilis, cardiovascular syphilis and gummatous syphilis - a rare granulomatous lesion of the skeleton, skin or mucocutaneous tissues. (such as perianal region, vulva, and scrotum). Mucous patches (superficial. Crohn's disease is a chronic inflammatory disease of the intestine and complex perianal fistulas are a severe and debilitating complication for which there is currently no effective treatment. Cx601 was granted orphan drug designation by the European Commission in 2009 and by the U.S Food and Drug Administration (FDA) in 2017 Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immunocompromised patients, disseminated infection. Mucocutaneous infections cause clusters of small painful.